Omegaflex Peri/Omegaflex Special

Per 1,250 mL Omegaflex Peri Glucose monohydrate 88 g (glucose 80 g), Na dihydrogen phosphate dihydrate 1.17 g, Zn acetate dihydrate 6.6 mg, medium-chain triglycerides 25 g, refined soya bean oil 20 g, omega-3-acid triglycerides (min 60% omega-3 acids) 5 g, isoleucine 2.34 g, leucine 3.13 g, lysine HCl 2.84 g (lysine 2.273 g), methionine 1.96 g, phenylalanine 3.51 g, threonine 1.82 g, tryptophan 0.57 g, valine 2.6 g, arginine 2.7 g, histidine HCl monohydrate 1.69 g (histidine 1.251 g), alanine 4.85 g, aspartic acid 1.5 g, glutamic acid 3.5 g, glycine 1.65 g, proline 3.4 g, serine 3 g, Na hydroxide 0.8 g, NaCl 1.081 g, Na acetate trihydrate 0.544 g, K acetate 2.943 g, Mg acetate tetrahydrate 0.644 g, Ca chloride dihydrate 0.441 g. Electrolytes: Na 50 mmol, K 30 mmol, Mg 3 mmol, Ca 3 mmol, Zn 0.03 mmol, Cl 48 mmol, acetate 40 mmol, phosphate 7.5 mmol. Amino acid 40 g, nitrogen 5.7 g, carbohydrate 80 g, lipid 50 g. Energy: 955 kCal. Per 1,875 mL Omegaflex Peri Glucose monohydrate 132 g (glucose 120 g), Na dihydrogen phosphate dihydrate 1.755 g, Zn acetate dihydrate 9.9 mg, medium-chain triglycerides 37.5 g, refined soya bean oil 30 g, omega-3-acid triglycerides (min 60% omega-3 acids) 7.5 g, isoleucine 3.51 g, leucine 4.695 g, lysine HCl 4.26 g (lysine 3.41 g), methionine 2.94 g, phenylalanine 5.265 g, threonine 2.73 g, tryptophan 0.855 g, valine 3.9 g, arginine 4.05 g, histidine HCl monohydrate 2.535 g (histidine 1.876 g), alanine 7.275 g, aspartic acid 2.25 g, glutamic acid 5.25 g, glycine 2.475 g, proline 5.1 g, serine 4.5 g, Na hydroxide 1.2 g, NaCl 1.622 g, Na acetate trihydrate 0.816 g, K acetate 4.415 g, Mg acetate tetrahydrate 0.966 g, Ca chloride dihydrate 0.662 g. Electrolytes: Na 75 mmol, K 45 mmol, Mg 4.5 mmol, Ca 4.5 mmol, Zn 0.045 mmol, Cl 72 mmol, acetate 60 mmol, phosphate 11.25 mmol. Amino acid 60 g, nitrogen 8.6 g, carbohydrate 120 g, lipid 75 g. Energy: 1,435 kCal. Per 1,250 mL Omegaflex Special Glucose monohydrate 198 g (glucose 180 g), Na dihydrogen phosphate dihydrate 3.12 g, Zn acetate dihydrate 8.78 mg, medium-chain triglycerides 25 g, refined soya bean oil 20 g, omega-3-acid triglycerides (min 60% omega-3 acids) 5 g, isoleucine 4.105 g, leucine 5.48 g, lysine HCl 4.975 g (lysine 3.982 g), methionine 3.42 g, phenylalanine 6.145 g, threonine 3.175 g, tryptophan 1 g, valine 4.505 g, arginine 4.725 g, histidine HCl monohydrate 2.96 g (histidine 2.191 g), alanine 8.49 g, aspartic acid 2.625 g, glutamic acid 6.135 g, glycine 2.89 g, proline 5.95 g, serine 5.25 g, Na hydroxide 1.464 g, NaCl 0.473 g, Na acetate trihydrate 0.313 g, K acetate 4.611 g, Mg acetate trihydrate 1.137 g, Ca chloride dihydrate 0.779 g. Electrolytes: Na 67 mmol, K 47 mmol, Mg 5.3 mmol, Ca 5.3 mmol, Zn 0.04 mmol, Cl 60 mmol, acetate 60 mmol, phosphate 20 mmol. Amino acid 70.1 g, nitrogen 10 g, carbohydrate 180 g, lipid 50 g. Energy: 1,475 kCal. Per 1,875 mL Omegaflex Special Glucose monohydrate 297 g (glucose 270 g), Na dihydrogen phosphate dihydrate 4.68 g, Zn acetate dihydrate 13.17 mg, medium-chain triglycerides 37.5 g, refined soya bean oil 30 g, omega-3-acid triglycerides (min 60% omega-3 acids) 7.5 g, isoleucine 6.158 g, leucine 8.22 g, lysine HCl 7.463 g (lysine 5.973 g), methionine 5.13 g, phenylalanine 9.218 g, threonine 4.763 g, tryptophan 1.5 g, valine 6.758 g, arginine 7.088 g, histidine HCl monohydrate 4.44 g (histidine 3.286 g), alanine 12.73 g, aspartic acid 3.938 g, glutamic acid 9.203 g, glycine 4.335 g, proline 8.925 g, serine 7.875 g, Na hydroxide 2.196 g, NaCl 0.71 g, Na acetate trihydrate 0.47 g, K acetate 6.917 g, Mg acetate tetrahydrate 1.706 g, Ca chloride dihydrate 1.169 g. Electrolytes: Na 100.5 mmol, K 70.5 mmol, Mg 7.95 mmol, Ca 7.95 mmol, Zn 0.6 mmol, Cl 90 mmol, acetate 90 mmol, phosphate 30 mmol. Amino acid 105.1 g, nitrogen 15 g, carbohydrate 270 g, lipid 75 g. Energy: 2,215 kCal

Omegaflex Peri Parenteral nutrition for adult patients in states of mild to moderate catabolism when oral/enteral nutrition is impossible, insufficient or contraindicated. Omegaflex Special Parenteral nutrition for adult patients in states of moderate to severe catabolism when oral/enteral nutrition is impossible, insufficient or contraindicated.

Omegaflex Peri Adult Individualised dosage via IV infusion into a peripheral or central vein. Max: 40 mL/kg/day. Max rate of infusion: 2.5 mL/kg/hr. Max treatment duration: 7 days. Omegaflex Special Adult Individualised dosage via central venous infusion only. Max: 35 mL/kg/day. Max rate of infusion: 1.7 mL/kg/hr.

Hypersensitivity to the active substances, to egg, fish, peanut or soya protein. Inborn errors of amino acid metabolism; severe hyperlipidaemia characterized by hypertriglyceridaemia (≥1,000 mg/dL or 11.4 mmol/L); severe coagulopathy; hyperglycaemia not responding to insulin doses of up to 6 u insulin/hr; acidosis; intrahepatic cholestasis; severe hepatic insufficiency; severe renal insufficiency in absence of renal replacement therapy; aggravating haemorrhagic diatheses; acute thromboembolic events, lipid embolism. Unstable circulatory status w/ vital threat (states of collapse & shock); acute phases of cardiac infarction & stroke; unstable metabolic condition (eg, severe postaggression syndrome, coma of unknown origin); inadequate cellular oxygen supply; disturbances of the electrolyte & fluid balance; acute pulmonary oedema; decompensated cardiac insufficiency. Must not be used in newborn infants, infants & toddlers <2 yr.

Exercise caution in cases of increased serum osmolarity; in patients w/ disturbances of lipid metabolism w/ increased serum triglycerides eg, renal insufficiency, DM, pancreatitis, impaired hepatic function, hypothyroidism (w/ hypertriglyceridaemia), sepsis, & metabolic syndrome. Correct fluid, electrolyte or acid-base imbalance before starting infusion. Too rapid infusion can lead to fluid overload w/ pathological serum electrolyte conc, hyperhydration & pulmonary oedema. Immediately interrupt infusion in case of any sign or symptom of anaphylactic reaction. Occasional hypertriglyceridaemia may occur. Triglyceride levels react to glucose, lipids & overnutrition in case of combined hyperlipidaemias & in metabolic syndrome. Can lead to hyperglycaemia. Monitor serum triglyceride & blood glucose conc during infusion. Commencing or recommencing nutrition therapy in malnourished or depleted patients may cause hypokalaemia, hypophosphataemia & hypomagnesaemia; closely monitor serum electrolytes. Controls of serum electrolytes, water balance, acid-base balance, & of blood cell counts, coagulation status, hepatic & renal function are necessary. Substitution of electrolytes, vit & trace elements may be necessary as required. Caution when co-administering w/ soln containing Zn, Mg, Ca & phosphate. Strongly advisable not to add to other soln. Risk of pseudoagglutination w/ simultaneous administration of blood in the same infusion set. Infusion in peripheral veins may cause thrombophlebitis (for Omegaflex Peri). Patients w/ DM, impaired cardiac or renal function. Patients on a Na-controlled diet. Fat content may interfere w/ certain lab measurements (eg, bilirubin, lactate dehydrogenase, oxygen saturation) if blood is sampled before fat has been adequately cleared from the blood stream. Should only be given to pregnant women after careful consideration. Breast-feeding is not recommended for mothers on parenteral nutrition. No clinical experience of use in childn & adolescents. Caution in elderly patients suffering from diseases eg, cardiac or renal insufficiency.

Omegaflex Peri Vein irritation, phlebitis or thrombophlebitis after a few days. Omegaflex Special Uncommon: Nausea, vomiting; loss of appetite.

Increased plasma lipolysis followed by a transient decrease in triglyceride clearance w/ heparin. Soya-bean oil (has natural content of vit K₁) may interfere w/ therapeutic effect of coumarin derivatives. Use w/ caution in patients receiving drugs that increase serum K conc (eg, K-sparing diuretics, ACE inhibitors, AIIA, ciclosporin, tacrolimus). Corticosteroids & ACTH are associated w/ Na & fluid retention.

Parenteral Nutritional Products

B05BA10 - combinations ; Belongs to the class of solutions for parenteral nutrition used in I.V. solutions.

P₁S₁S₃